Affordable Depression Treatment Centers-The success of each therapy depends largely on how much the patient is willing and able to adhere to the therapy plan discussed with the doctor. In medicine one speaks of therapy fidelity or compliance. The problem of non-compliance often occurs in diseases, the extent and consequences of which are underestimated by the patient. Especially if the disease, as is the case with depression, is in phases with times more and sometimes less severe impairments, patients tend to expose the therapy in good phases. However, this increases the risk of more serious reoccurrences.
The best way to improve therapy fidelity is to educate. The doctor must take the time to explain what a depression is, what the importance of therapy is, and what consequences an untreated depression can have. The patient must also be informed about possible side effects of the antidepressant medications. He should also know that the antidepressant effect can often only be used after 2 or 3 weeks.
It is important to adapt the treatment plan to the needs and conditions of the patient. In the case of severely depressed people who can only cope with a very limited daily routine, close therapeutic care is required. In many cases, it makes sense that, in agreement with the patient, relatives are informed and involved so that they can support the diseased.
Medications for the treatment of depression are referred to as antidepressants. They interfere with brain metabolism. They are intended to regulate the disturbed communication between the nerve cells by influencing the quantity and activity of the messenger substances. The various biochemical active substances that are used are aimed at the messenger substances serotonin, dopamine, norepinephrine and melatonin.
According to their mechanism of action, antidepressants are divided into different classes. Depending on the acute condition of the disease and the predominant symptoms, the doctor decides which drug is best suited for which active class. The impact profile also plays a role.
Massa (melatonin agonist and specific serotonin antagonist): This drug, which is approved for episodes of depression in adults, is referred to as melatonerges antidepressant. It has, among other things, the activeness of the messenger substance melatonin, which is responsible for the cessation of biological rhythms. This ‘ melatonin agonist and specific serotonin antagonist ‘ takes over melatonerge binding points directly affecting the human’s internal clock. At the same time, it inhibits certain serotonin binders on the nerve cells, thereby releasing a greater proportion of the messenger substances norepinephrine and dopamine in certain brain regions. The interplay of these receptors, on the one hand, causes a normalization of the disturbed biorhythm of depressed patients, i.e. it balances the circadian rhythm with the natural day-night rhythm, on the other hand an improvement of the depressive symptoms such as Disturbance of mood, affect and daily activity as well as anxiety symptoms. The Melatonerge antidepressant has a favorable impact profile. It is neutral in terms of body weight, heart rate and blood pressure and receives sexual function. Temporarily, it can come to nausea and dizziness after ingestion. There are also reports of insomnia, liver value increase, headaches and sweating.
Modern antidepressants engage more specifically in the activity of special messenger substances. This makes them much better tolerated.
SSRI (selective serotonin reuptake inhibitors): These reuptake inhibitors influence the composition of the messenger substances between the nerve cells in the synaptic gap. SSRI block the specific serotonin receptors on the distributing nerve cell, thereby preventing the return of serotonin to the nerve cell. Consequently, the concentration of serotonin in the synaptic gap increases (see page 5). This has a mood-brightening, generally activating and anxiety-solving effect. However, undesirable side effects are also known. These include: nausea and diarrhea, sexual dysfunction, dry mouth, headaches and sleep disorders.
NARI (selective norepinephrine-reuptake inhibitors): NARI regulate the equilibrium of the messengers by blocking the receptors for the resumption of the messenger norepinephrine and thereby increasing its concentration in the synaptic gap. The therapeutic effect is shown above all in an improved drive and the increase of motivation. Side effects include constipation, dry mouth, increased perspiration, disturbances in bladder emptying, headaches and sleep disorders.
SNRI (serotonin-norepinephrine-reuptake inhibitors): Drugs of this active class inhibit both the resumption of the messenger serotonin and the resumption of the messenger substance norepinephrine. This has a mood-brightening and in higher dosages drive-enhancing effect. Possible side effects are similar to SSRI, nausea, sleep disorders, sexual dysfunction, dry mouth and headache. It can also cause dizziness, lack of appetite and high blood pressure.
Wetta (Noradrenerge and specifically serotonergic antidepressants): these modern antidepressants stimulate the distribution of the messenger substances norepinephrine and serotonin, thus increasing their concentration in the synaptic gap. On the list of possible side effects are fatigue, dizziness, headache, weight gain as well as circulatory problems due to low blood pressure.